فاند دکتری عصب سناسی دانشگاه کورک ایرلند

PhD Studentship in Molecular Neuroscience

Applications are invited for a PhD position in the laboratory of Dr Paul Young in the School of Biochemistry and Cell Biology, University College Cork, Ireland.

Project Title

Investigation of LNX proteins as novel regulators of synaptic function and potential drug targets in neurological disorders.

Project Details

LNX1 and LNX2 proteins are closely related E3 ubiquitin ligases that are expressed in neurons. We have described anxiety-related behavioural abnormalities in mice lacking LNX1 and/or LNX2.  Taking advantage of our access to LNX1 and LNX2 knockout mice, this project seeks to identify the developmental processes, neural circuit(s) and molecular mechanisms by which loss of LNX function leads to these behavioural alterations.  The project will also identify the molecular interactions that are relevant to LNX protein function in vivo.  Overall, the project will provide novel insights into the molecular mechanisms underlying brain circuits that control behaviours of relevance to anxiety and autism spectrum disorders and potentially support further investigation of LNX proteins as novel drug targets.

Key Reference:

• Young PW: LNX1/LNX2 proteins: functions in neuronal signaling and beyond. Neuronal Signaling 2018, 2(2):1-20. https://doi.org/10.1042/NS20170191

Position

• The PhD candidate will conduct a specified programme of research under the supervision of Dr Paul Young
• The position will be based in the School of Biochemistry and Cell Biology, UCC, with the possibility of some travel for international collaboration

Criteria

• Minimum 2:1 undergraduate degree (or equivalent) in biochemistry, neuroscience, physiology, molecular biology, genetics or a similar discipline
• An MSc or additional relevant research experience would be advantageous
• Applicant must be willing to work with laboratory mice
• Good communication, organisational, teamwork and interpersonal skills
• Applicants whose first language is not English must show evidence of English proficiency, please check the minimum requirements at https://www.ucc.ie/en/study/comparison/english/

Funding Details

This full-time PhD position funded by Science Foundation Ireland for up to 4 years including a stipend of €۱۸,۵۰۰ per annum. The studentship will cover fees at the rate for EU students.